Program

Download the short program here;
and the complete program (including abstracts) here.

Connect to the WebApp for the GSCN Conference 2021 Link.

Auditorium; whole (AUD); Auditorium; left (AUD/L); Auditorium; right (AUD/R); Seminar room 2nd floor (SR)

Wednesday

Thursday

Friday

Wednesday, 6 October 2021

	Opening
11:00 - 11:30 AUD	GSCN Conference 2021
11:00 - 11:10	Welcome to the Center for Regenerative Therapies (CRTD) at the TU Dresden Federico Calegari, Director CRTD
11:10 - 11:20	Greeting address of the Berlin Institute of Health (BIH) Christopher Baum, Chairman of the Board of Directors of the BIH at Charité
11:20 - 11:30	Welcome to GSCN Conference 2021 Hans Schöler, President GSCN
11:30 - 12:15 AUD	Keynote lecture I K1 - Regulation of stem cell fate by niche-derived factors and forces Sara Wickström, University of Helsinki, Finland Chair: Hans Schöler
12:15 - 13:00 AUD	Keynote lecture II K2 - Hepato-biliary-pancreatic organogenesis in a dish Takanori Takebe, Cinncinati Children's Hospital Medical Center, OH, USA Chair: Hartmut Geiger
13:00 - 14:30	Break time / Industry exhibition
	Concurrent scientific working group session I
14:30 - 16:00 AUD/L	Stem cells in disease modeling and drug development (Chairs: Oliver Brüstle / Karl-Ludwig Laugwitz)
14:30 - 14:55	T01 - Human iPSCs and 3D model systems for translational cardiovascular medicine Christian Kupatt, TU Munich
14:55 - 15:08	T02 - Characterization of a novel in vitro cardiomyocyte developmental disease model with hPSCs by chromatin remodelling Emiliano Bolesani, Hannover Medical School (MHH)
15:08 - 15:21	T03 - Inceptor is a novel regulator of insulin signaling, synthesis and degradation in human iPSC-derived beta cells Johanna Siehler, Helmholtz Zentrum München
15:21 - 15:34	T04 - Rapid generation of human sensory neurons from iPSC by overexpression of NGN1, BRN3A and ISLET1 Pascal Röderer, University of Bonn, Institute of Reconstructive Neurobiology, Bonn
15:34 - 15:47	T05 - Failure to repress non-neuronal genes in neurons can cause autistic-like phenotypes Moritz Mall, German Cancer Research Center (DKFZ), Heidelberg
15:47 - 16:00	T06 - SARS-CoV-2 infects the brain vasculature in COVID-19 patients which can be mimicked with an hiPSC-derived model of the blood-brain barrier Undine Haferkamp, Fraunhofer ITMP, ScreeningPort, Hamburg
14:30 - 16:00 AUD/R	Somatic stem cells and development (Chairs: Federico Calegari / Ana Martin-Villalba)
14:30 - 15:00	T07 - Regeneration of the adult vertebrate brain: learning from the fish Michael Brand, CRTD Dresden
15:00 - 15:15	T08 - ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation Tianliang Sun, Novartis Institutes for BioMedical Research, Basel, CH
15:15 - 15:30	T09 - Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification Kai Kretzschmar, University Hospital Würzburg
15:30 - 15:45	T10 - Generation of rat spermatozoa in sterile mice utilizing blastocyst complementation with pluripotent stem cells Joel Zvick, ETH Zürich, CH
15:45 - 16:00	T11 - Basal neural stem cells drive postnatal neurogenesis whereas apical stem cells act as proliferation gatekeepers by regulating notch activation in the postnatal ventricular-subventricular zone Katja Baur, University of Heidelberg
14:30 - 16:00 SR	Computational stem cell biology (Chairs: Carsten Marr / Ingmar Glauche)
14:30 - 15:00	T12 - RNA velocity, fate mapping, modeling: tools to quantify haematopoiesis Melania Barile, MRC Cambridge Stem Cell Institute, UK
15:00 - 15:15	T13 - Clonal reconstruction from co-occurrence of vector integration sites allows accurate quantification of expanding clones in vivo Ingmar Glauche, TU Dresden
15:15 - 15:30	T14 - Predicting nuclei displacement and transcription factor expression from highthroughput 3D brightfield organoids Dominik Waibel, HelmholtzZentrum München, Munich
15:30 - 15:45	T15 - Population dynamics, the role of interferons and molecular underpinnings of neural stem cell maintenance Jooa Hooli, DKFZ Heidelberg
15:45 - 16:00	T16 - Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states Lea Jopp-Saile, DKFZ and HI-STEM Heidelberg
16:00 - 16:30	Break time / Industry exhibition
16:30 - 17:30	GSCN General Membership Meeting GSCN Executive Board
17:30 - 19:30	Poster session I (Poster numbers: P001 - P051) Pluripotency & Reprograming: P001 - P015 Stem cells in disease modeling and drug development: P016 - P051 Even numbers: 17:30 - 18:30 Odd numbers: 18:30 - 19:30
19:45 - 20:30 AUD/L	Keynote lecture III K3 - Gastruloids: an ESC based model for mammalian gastrulation and body plan engineering Alfonso Martinez Arias, ICREA and Universidad Pompeu Fabra, Barcelona, Spain Chair: Tobias Cantz
20:30 - 22:00	Informal GSCN get-together for all participants with dinner buffet in the Foyer
	Top

Thursday, 7 October 2021

09:00 - 10:30	Concurrent scientific working group session II
09:00 - 10:30 AUD/L	Organoids: new models for diseases (Chairs: Mina Gouti / Heiko Lickert)
09:00 - 09:30	T17 - Building advanced human neuromuscular organoids to study development and disease Mina Gouti, MDC Berlin
09:30 - 09:45	T18 - Patient-specific iPSC for characterization of unclear intrahepatic cholestasis in hepatobiliary organoids Lennart Dignas, Hannover Medical School (MHH)
09:45 - 10:00	T19 - USP42 forms a tug-of-war with R-spondin to control Wnt activity in intestinal stem cells Sergio Perez Acebron, Heidelberg University
10:00 - 10:15	T20 - A neural organoid based drug screen for targets of Huntington’s disease Jakob Metzger, MDC Berlin
10:15 - 10:30	T21 - Developing a new generation of human brain disease models using CRISPR editing and iPS cells Dominik Paquet, Ludwig Maximilian University of Munich
09:00 - 10:30 AUD/R	Stem cells in regenerative therapies I (Chairs: Michael Cross / Hannes Klump)
09:00 - 09:30	T22 - Stem cells meet cell-based immunotherapies, the hope behind regenerative medicine Nico Lachmann, Hannover Medical School (MHH)
09:30 - 09:45	T23 - Inflammation-responding mesenchymal stromal cells modulate the bone marrow microenvironment response to stress over time Shubhankar Sood, German Cancer Research Center, Heidelberg
09:45 - 10:00	T24 - Mesenchymal stromal cells for treatment of tendon injuries: first insights from a controlled, randomized, blinded veterinary patient study Janina Burk, Justus-Liebig-University Giessen
10:00 - 10:15	T25 - Transgene-free direct reprogramming of mouse fibroblasts into myogenic progenitors utilizing modified mRNA and small molecules Xhem Qabrati, ETH Zürich
10:15 - 10:30	T26 - Allele-specific targeting of mutant ataxin-3 by antisense oligonucleotides in SCA3-iPSC-derived neurons Stefan Hauser, German Center for Neurodegenerative Diseases (DZNE), Tübingen
09:00 - 10:30 SR	Stem cells in ageing and disease (Chairs: Michael Rieger / Andreas Trumpp)
09:00 - 09:30	T27 - Stem cells in ageing and disease Hartmut Geiger, Ulm University
09:30 - 09:45	T28 - Mathematical modelling of immune response in CML patients suggests potential for TKI reduction prior to cessation Thomas Zerjatke, TU Dresden
09:45 - 10:00	T29 - Mathematical modeling of chronic lymphocytic leukemia cell kinetics under therapy with Ibrutinib Melanie Schulz, HelmholtzZentrum München, Munich
10:00 - 10:15	T30 - Aging stem cell biology – convergence of murine and human hematopoietic systems Nina Henning, Leibniz Institute on Aging, Jena
10:15 - 10:30	T31 - A Taz/PU.1 loop protects aged hematopoietic stem cells from functional decline Bjoern von Eyss, Leibniz Institute on Aging, Jena
10:30 - 11:00	Break time / Industry exhibition
11:00 - 12:30	Industry session: "Technologies from GSCN industry partners"
11:00 - 12:30 AUD/L	Supporter I (Chairs: Marieke Essers / Stefan Liebau)
11:00 - 11:30	C01 - A look into the full solution: Sartorius’ efforts and offers to ATMPs Vinay Murtadak, Sartorius
11:30 - 12:00	C02 - Process intensification through automated feedback process control for high-yield stem cell culture Philipp Nold, Eppendorf AG
12:00 - 12:15	C03 - OPTi-OX™: a next generation cellular reprogramming technology - highly defined and functional human iPSC-derived cell models for research and drug discovery Roisin Nicoll, bit.bio
12:15 - 12:30	C04 - A novel benchtop approach for high-yield, improved viability and long-term cultivation of 3D cell models Markus Uhrig, OLS – OMNI Life Science GmbH & Co. KG
11:00 - 12:30 AUD/R	Supporter II (Chairs: Heiko Lickert / Claudia Waskow)
11:00 - 11:30	C05 - 10x Genomics Chromium Multiome solution for the analysis of gene regulation at single cell resolution Hannes Arnold, 10x Genomics
11:30 - 12:00	C06 - Simplifying the development of hiPSC-based disease models Florian Paasch, Takara Bio Europe
12:00 - 12:15	C07 - New generation of hPSC cell culture media is ready for challenging applications Sebastian Knöbel, Miltenyi Biotec B.V. & Co. KG
12:15 - 12:30	C08 - How to evaluate recombinant proteins, cytokines, and growth factors Fiona Bellot, Proteintech Group
11:00 - 12:30 SR	Supporter III (Chairs: Thomas Braun / Nina Cabezas-Wallscheid)
11:00 - 11:15	C09 - Modular biomimetic matrices enable highly defined culture of functional stem cells Dejan Husman, denovoMATRIX
11:15 - 11:30	C10 - CTS™ NK-Xpander™: a feeder-free NK cell expansion medium for cell therapy Roland Leathers, Thermo Fisher Scientific
11:30 - 11:45	C11 - Next generation brain-region-specific organoid models Katharina Debowski, STEMCELL Technologies GmbH
11:45 - 12:00	C12 - Moving towards animal-free cell culture media: human platelet lysate as surrogate solution for FBS Roman Goetzke, PL BioScience GmbH
12:00 - 12:15	C13 - Harnessing the power of live cell imaging: performing high-throughput and high-content experiments using the CELLCYTE X and Livecyte imaging systems Jim Engström, CYTENA GmbH
12:15 - 12:30	C14 -Optimizing tools required for the discovery and development of stem cell-based models Volker Arps, Bio-Techne
12:30 - 14:00	Break time / Industry exhibition
13:00 - 14:00	Meet-the-expert tables (limited to 10 participants each, registration is possible at the registration desk) Nico Lachmann, Hannover Medical School (MHH); Heiko Lickert, Helmholz Zentrum München; Sara Wickström, University of Helsinki, FIN
14:00 - 16:15 AUD	Presidential Symposium Chair: Hans Schöler
14:00 - 14:45	Presidential Invite PS1 - Mechanisms regulating tumor transition states Cédric Blanpain, Université Libre de Bruxelles, Brussels, Belgium
14:45 - 15:15	GSCN 2021 Young Investigator Award PS2 - The role of resident macrophages in health and disease Elvira Mass, Limes Institute, University Bonn
15:15 - 15:45	GSCN 2021 Hilde Mangold Award PS3 - Developmental biology-inspired approaches for regenerative medicine Katja Schenke-Layland, Eberhard Karls University Tübingen
15:45 - 16:15	GSCN Publication of the Year 2020/21 Award PS4 - Epithelial cell plasticity drives endoderm formation during gastrulation Katharina Scheibner, HelmholtzZentrum München
16:15 - 16:30	Break Time / Industry exhibition
16:30 - 18:30	Poster session II (Poster numbers: P052 - P101) Hematopietic stem cells: P052 - P057 Organoids: new models for diseases: P058 - P064 Computational stem cell biology and systems biology: P065 - P068 Somatic stem cells and development: P069 - P079 Stem cells in ageing and disease: P080 - P083 Stem cells in regenerative therapies: P084 - P095 Stem cells in regenerative therapies: mesenchymal stromal cells: P096 - P101 Even numbers: 16:30 - 17:30 Odd numbers: 17:30 - 18:30
19:30 - 01:00	GSCN Networking evening for all participants
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Friday, 8 October 2021

09:00 - 10:30	Concurrent scientific working group session III
09:00 - 10:30 HS left	Pluripotency and reprograming (Chairs: Micha Drukker / Frank Edenhofer)
09:00 - 09:30	T32 - XEN state reprogramming into self-organizing trophectoderm-like cells enables the assembly of synthetic embryoids Ivan Bedzhov, MPI Münster
09:30 - 09:45	T33 - Functional genomic screening during somatic cell reprogramming identifies DKK3 as a roadblock of organ regeneration Frank Arnold, University Hospital Ulm
09:45 - 10:00	T34 - Integrative molecular roadmap for reprogramming fibroblasts into induced myogenic stem and progenitor cells Inseon Kim, ETH Zürich, CH
10:00 - 10:15	T35 - Harnessing the regenerative potential of cortical glia through Ascl1-mediated lineage reprogramming Sophie Péron, Johannes Gutenberg University Mainz
10:15 - 10:30	T36 - Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3 Michelle Vincendeau, Helmholtz Zentrum München
09:00 - 10:30	Stem cells in regenerative therapies II (Chairs: Ulrich Martin / Wolfgang Wagner)
09:00 - 09:30	T37 - Translating tissue engineered heart repair Wolfram-Hubertus Zimmermann, University Hospital Göttingen
09:30 - 09:45	T38 - Cardiac optogenetic technologies for investigation of the electrophysiological properties in 2D and 3D stem cell-derived cardiac derivatives Maria Ricci Signorini, Hannover Medical School (MHH)
09:45 - 10:00	T39 - Dynamic gene expression controls muscle stem cell fate Ines Lahmann, Max Delbrück Center (MDC), Berlin
10:00 - 10:15	T40 - Pancreatic differentiation guided by tissue-specific extracellular matrix Constatin Berger, University Hospital Würzburg
10:15 - 10:30	T41 - Universal upscaling strategy for high-density bioprocessing of human pluripotent stem cells in stirred bioreactors Felix Manstein, Hannover Medical School (MHH)
09:00 - 10:30	Hematopoietic stem cells (Chairs: Nina Cabezas-Wallscheid / Elvira Mass)
09:00 - 09:30	T42 - Repetitive elements as signals for developmental and regenerative hematopoiesis Eirini Trompouki, MPI Freiburg
09:30 - 09:45	T43 - Glucose internalization of hematopoietic stem cells defines their function and potential Mona Vogel, Ulm University
09:45 - 10:00	T44 - Mitochondrial active hematopoietic stem cells can long-term reconstitute lymphomyeloid blood cells Malak Fawaz, Goethe University Hospital Frankfurt
10:00 - 10:15	T45 - Embryo-derived bone macrophages regulate the pool size of HSCs Gülce Percin, Leibniz Institute on Aging, Jena
10:15 - 10:30	T46 - Emergency megakaryopoiesis is independent of MPL/THPO axis during influenza infection Marcel Rommel, Paul Ehrlich Institute, Langen
10:30 - 11:00	Break Time / Industry exhibition
11:00 - 12:30	Concurrent scientific working group session
11:00 - 12:30	Clinical trials and regulatory affairs (Chairs: Zoltan Ivics / Anndreas Kurtz)
11:00 - 11:30	S01 - Inflammation-responding mesenchymal stromal cells modulate the bone marrow microenvironment response to stress over time Marieke Essers, HI-STEM and DKFZ, Heidelberg
11:30 - 12:00	S02 - Metabolism guides definitive lineage specification during endothelial to hematopoietic transition Niels-Bjarne Woods, Lund University
12:00 - 12:30	S03 - Advanced curative options for hemoglobinopathies in the era of gene editing Selim Corbacioglu, University of Regensburg
11:00 - 12:30	Career development (Chairs: German Camargo Ortega / Insa Schröder)
11:00 - 12:30	S04 - Erfolgreiche Gesprächsführung mit Advisors: Strategien und Zielsetzung (DE) Nele Haasen, konteam
11:00 - 12:30	Technologies in stem cell research (Chairs: Andreas Bosio / Sebastian Diecke)
11:00 - 11:30	S05 - A resource of clincal-grade human iPS cells with immune compatibility to the caucasian population Boris Greber, RheinCell Therapeutics, Langenfeld (Rheinland)
11:30 - 12:00	S06 - Universal donor iPSC lines for regenerative medicine – tailored to escape the immune system? Malte Tiburcy, University Hospital Göttingen
12:00 - 12:30	S07 - iPSC-based therapies: manufacturing of clinical-grade cell products and considerations concerning autologous vs allogeneic concepts Ulrich Martin, Hannover Medical School
12:30 - 14:00	Break Time / Industry exhibition
13:00- 14:00	Meet-the-expert-table (limited to 10 registered participants each, registration is possible at the registration desk) Tobias Cantz, Hannover Medical School (MHH), Mina Gouti, MDC Berlin; Elvira Mass, LIMES Institute Bonn
14:00 - 14:45	EMBO Keynote lecture K4 - Stem cells, embryos and embryo models Janet Rossant, SickKids Research Institute, Toronto Chair: Claudia Waskow
14:45 - 15:30	EMBO YIP Lecture K5 - Symmetry breaking and self- organization in intestinal organoids Prisca Liberali, Friedrich Miescher Institute, Basel, Switzerland Chair: Stefan Liebau
15:30 - 15:50	Poster award ceremony Daniel Besser
15:50 - 16:00	Closing remarks by the GSCN president Hans Schöler
	End of GSCN Conference 2021
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GSCN iPoster Session

The poster session at the conference is displayed on ePoster terminals on the 2^nd floor of the CRTD. All posters can also be viewed online on laptop computers and tablets by all participants. You can also view the posters beforehand online, and we strongly recommend doing so. Please, contact the authors and make an appointment for intense and detailed discussion of the data. Beside this online option, there will be two poster sessions onsite as usual and we are looking forward to intense discussion, exchange of data and new findings.

The sign-in page is:
https://gscn2021.ipostersessions.com
You only need your participant e-mail address for log-in.

GSCN Hygiene Concept Dresden

The GSCN Conference will only accept participants with a complete vaccination (plus 14 days) or recovered, confirmed by Corona Warn-App or CovPass App.

During the conference days each participant will have to be daily tested and present the negative result at the entrance. There will be a test center at the venue!

Tuesday, 5.10., 8 hr – 15 hr & from 16 hr
Wednesday 6.10, 9 hr – 13 hr (one Tester till 18 hr)
Thursday, 7.10., 8 hr – 11 hr (one Tester till 18 hr),
Friday, 8.10, 8 – 11 hr

Please consider waiting time for the result and due to other participats undergoing the testing.

Keynote Speakers

Cédric Blanpain (Brussels, BE)