Download the short program  here;
the complete program (including abstracts) is available for participants on 📧 demand.
The program is also available as an  Online App at the start of the GSCN conference.     supported by Life & Brain GmbH

Wednesday Thursday Friday

Wednesday, 13 September 2023

11:00 - 11:30
H 4/5
GSCN Conference 2023
11:00 - 11:10 Welcome to Ulm University
Thomas Wirth, Dean of the Medical Faculty of the University of Ulm
11:10 - 11:20 Welcome to the city of Ulm
Hartmut Geiger, Local Organizer and Former President GSCN 2019 - 2020
11:20 - 11:30 Opening of GSCN Conference 2023
Claudia Waskow, President GSCN
11:30 - 12:15
H 4/5
Keynote lecture I
K1 - Mechanisms driving clonal hematopoiesis
Margaret Goodell, Baylor College of Medicine, Houston, Texas, US
Chair: Claudia Waskow
12:15 - 13:00
H 4/5
Keynote lecture II
K2 - Stem cell niches and beyond
Hiromitsu Nakauchi, Stanford Medicine, California, US
Chair: Alexander Kleger
13:00 - 14:30 Lunch break / Industry exhibition    supported by denovoMatrix GmbH
14:30 - 16:00 Concurrent scientific working group session I
14:30 - 16:00
H 1
Stem cells in disease modeling & drug development I                                                                                       supported by
(Chairs: Oliver Brüstle / Karl-Ludwig Laugwitz)
14:30 - 15:00 T01 - Quality-controlled and well-characterized human pluripotent stem cells: a foundation for reproducible disease modeling and drug screening
Harald Stachelscheid, Berlin Institute of Health (BIH) at Charité
15:00 - 15:15 T02 - RB1-negative organoids model retinoblastoma with proliferation of cone photoreceptors and loss of retinal cell type differentiation
Julia Wöstefeld, University hospital Essen
15:15 - 15:30 T03 - Investigating the impact of ELP1 predisposition on SHH-medulloblastoma tumorigenesis: insights from iPSC-derived models
Frederik Manz, Hopp Chidrens's Cancer Center (KiTZ) Heidelberg
15:30 - 15:45 T04 - Primary ciliary dyskinesia patient-specific hiPSC-derived airway epithelium in air-liquid interface culture recapitulates disease specific phenotypes in vitro
Laura von Schledorn, Hannover Medical School (MHH)
15:45 - 16:00 T05 - Unraveling the role of long non-coding RNAs in pancreatic development and ß-cell functionality
Sarah Merz, Ulm University
14:30 - 16:00
H 2
Pluripotency & reprograming   supported by Miltenyi Biotec B.V.& Co. KG
(Chairs: Micha Drukker / Hans Schöler)
14:30 - 15:00 T06 - Reprogramming toward next-generation stem cell models with re-engineered transcription factors
Ralf Jauch, University of Hong Kong, China
15:00 - 15:15 T07 - Single cell mass cytometry analysis identifies Nacc1, a known pluripotent stem cell regulator to also regulate totipotent stem cell fate of embryonic stem cells
Thulaj Mehawarde, Montreal Clinical Research Institute, Canada
15:15 - 15:30 T08 - Highly cooperative chimeric super-SOX induces naïve pluripotency across species
Caitlin McCarthy, MPI for Molecular Biomedicine, Münster
15:30 - 15:45 T09 - Zic3 and Otx2 link Xist activation to the formative pluripotency network
Till Schwaemle, MPI for Molecular Genetics, Berlin
15:45 - 16:00 T10 - Reprogramming activates those 55 specific polymorphic, functional LINE-1 loci in pluripotent stem cell genomes that are mobilized in human tumor cells
Gerald Schumann, Paul Ehrlich Institute, Langen
14:30 - 16:00
H 3
Computational stem cell biology
(Chairs: Ingmar Glauche / Carsten Marr
14:30 - 15:00 T11 - Cell fate patterns in preimplantation mouse embryos
Sabine Fischer, University of Würzburg
15:00 - 15:15 T12 - Challenges in machine-learning based detection of measurable residual disease in acute myeloid leukemia
Friedemann Uscher, Technical University Dresden
15:15 - 15:30 T13 - Shedding light on spatial changes of the septin network within LT-HSCs upon aging with open-source software CellDetail
Tanja Schuster, Ulm University
15:30 - 15:45 T14 - Developmental trajectories of adult B-cell Acute Lymphoblastic Leukemia (BCP-ALL)-initiating cells at a single-cell level
Adrien Jolly, Goethe University Hospital, Frankfurt
15:45 - 16:00 T15 - Gene expression noise dynamics unveil functional heterogeneity of ageing hematopoietic stem cells
Reyna Edith Rosales Alvarez, University of Würzburg
16:00 - 16:30 Break time / Industry exhibition      supported by Thermo Fisher Scientific
16:30 - 17:30
H 2
General Meeting
Executive Board & Managing Director
Claudia Waskow, Hans Schöler, Heiko Lickert, Michael Cross, Andreas Trumpp, Daniel Besser
17:30 - 19:30
Poster session I  (Poster number P001-P061)                                                                              supported by OLS OMNI Life Science GmbH
(with beverages)
Somatic stem cells & development: P001 - P008
Stem cell organoids: P009 - P017
Disease modeling & drug development: P018 - P061

Even numbers: 17:30 - 18:30
Odd numbers: 18:30 - 19:30
19:45 -20:30
H 4/5
Keynote lecture III (on ELSA topics)
K3 - Modeling mouse and human development with stem cells: the science and the ethics
Nicolas Rivron, IMBA, Austrian Academy of Science, Vienna, Austria
Chair: Aljoscha Berve
20:30 - 22:00
GSCN Get-together for all participants
Dinner buffet in the Foyer


Thursday, 14 September 2023

09:00 - 10:30 Concurrent scientific working group session II
09:00 - 10:30
H 1
Stem cells in disease modeling & drug development II
(Chairs: Bert Klebl / Harald Stachelscheid)
09:00 - 09:15 T16 - TPP1 gene therapy ablates disease phenotype in neuronal ceroid lipofuscinosis type 2 in retinal organoid and retina-on-chip models
Kevin Achberger, University of Tübingen
09:15 - 09:30 T17 - A human iPSC model of Tauopathies engineered for adult Tau isoform expression displays late-stage neuronal Tau pathology
Angelika Dannert, Ludwig Maximilians University (LMU), Munich
09:30 - 09:45 T18 - Beyond cell-autonomous phenotypes: multi-compartment modeling of human nociception
Pascal Röderer, University of Bonn
09:45 - 10:00 T19 - An isogenic human iPSC model unravels neurodevelopmental abnormalities in spinal muscular atrophy
Natalia Rodriguez-Muela, German Center for Neurodegenerative Diseases (DZNE), Dresden 
10:00 - 10:15 T20 - Characterizing the neurotoxic effects of paclitaxel in human induced pluripotent stem cell (iPSC)-derived sensory neurons in a multi-omic approach
Christian Schinke, Charité - Berlin University Medicine
10:15 - 10:30 T21 - Modeling metastatic cancer niches for drug discovery using human iPSC-derived brain organoids
Ole Pless, Fraunhofer ITMP Hamburg
09:00 - 10:30
H 2
Stem cell organoids 
(Chairs: Sina Bartfeld / Mina Gouti)
09:00 - 09:30 T22 - 3D electrically excitable cell networks - from brain to heart
Maria-Patapia Zafeiriou, University Medical Center Göttingen
09:30 - 09:45 T23 - Inducing lung differentiation in human heart-forming organoids to form complex lung-HFOs
Lika Drakhlis, Hannover Medical School (MHH)
09:45 - 10:00 T24 - Development of a skin cancer model using melanoma tumor spheroids and skin organoids
Dieter Groneberg, Fraunhofer-Institute for Silicate Research ISC, Würzburg
10:00 - 10:15 T25 - Modeling Johanson-Blizzard syndrome (JBS) in a dish – molecular insights into UBR1 deficiency using pluripotent stem cell-derived pancreatic organoids
Leon Reichardt, Ulm University
10:15 - 10:30 T26 - Generating fetal liver organoids with innate immunopoiesis from human pluripotent stem cells
Milad Rezvani, Charité - Berlin University Medicine
09:00 - 10:30
H 3
Stem cells in ageing & disease
(Chairs: Michael Rieger / Andreas Trumpp)
09:00 - 09:30 T27 - Bone marrow stromal dysregulations in clonal hematopoiesis and related myelodysplasia promote an inflammatory-stress T cell landscape
Borhane Guezguez, DKTK - University Medical Center Mainz
09:30 - 09:45 T28 - Ontogenetic and functional heterogeneity of tissue resident macrophages during aging and systemic inflammation
Stephan Culemann, Leibniz Institute on Aging/FLI, Jena
09:45 - 10:00 T29 - Single-cell barcoding delineates a differentiation hierarchy of leukemia-initiating stem cells in adult acute lymphoblastic leukemia
Alec Geßner, Goethe University Hospital, Frankfurt
10:00 - 10:15 T30 - Stem cell-niche interactions control leukemic expansion: conceptual insights from the mathematical modeling of acute myeloid leukemia
Ingmar Glauche, Technical University (TU) Dresden
10:15 - 10:30 T31 - Elevated levels of Ube2g1 expression in HSCs leads to premature aging of the hematopoietic system
Julian Niemann, Ulm University
09:00 - 10:30
ELSA symposium: What makes it (not) a human being?
(Chairs: Aljoscha Berve / Tobias Cantz)
Panelists: Nicolas Rivron & Hiromitsu Nakauchi
09:00 - 09:05 Welcome and introduction
Tobias Cantz, Hannover Medical School
09:05 - 09:15 Interview Nicolas Rivron with Aljoscha Berve, Stemcell Network NRW, Düsseldorf
What is your definition of embryoids, blastoids, self-assembled embryos and do these differences matter?
Do you think the term “synthetic embryo” is justified”? 
What are your expectations on advanced embryoid cultivation in 10 years?
How do differing international regulations affect your current research?
Do you experience global differences in acceptance / funding options of your research?
09:15 - 09:25 Interview Hiromitsu Nakauchi with Tobias Cantz
What are your expectations on the use of human-animal chimera for organ development in 10 years?
If an organ is generated by embryo complementation with patient-derived iPS cells. Who owns the organ?
Germline contribution of human cells is a critical issue. But to what extent does neural chimerism matter?
How do differing international regulations affect your current research?
Do you experience global differences in acceptance / funding options of your research?
09:25 - 10:15 Panel discussion / plenum:
What characteristics are missing to make an embryoid a human being? And, what is missing to make a chimeric animal a human being?
Subsequent to the term “synthetic embryo”, do we have to contemplate the term “synthetic human being”? 
Are there “safety switches” that would address major doubts?
Could we envision a road map that guides a step-wise development advanced embryoids human-animal chimeras? 
10:15 - 10:20 Concluding remarks
Aljoscha Berve
10:20 - 10:30 Civey survey on embryo research regulation in Germany 
How does the German (internet) public feel about embryo research regulation?
Daniel Besser
10:30 - 11:00 Break time / Industry exhibition        supported by Axion BioSystems
11:00 - 12:30 Industry session: "Technologies from GSCN industry partners"
11:00 - 12:30
H 4/5
Gold & Silver Supporter 
(Chair: Michael Cross)
11:00 - 11:30 C01 - Life & Brain integrated services: molecular karyotyping for cost-effective quality control of stem cell systems
Michael Peitz, Life & Brain GmbH
11:30 - 12:00 C02 - Enhanced genetic stability of human pluripotent stem cells maintained as single cells under optimized culture conditions
Kimberly Snyder, STEMCELL Technologies Inc., Vancouver, BC, Canada
12:00 -12:30 C03 - Replace, Reduce, and Refine with Bio-Techne – kick-start your animal-free research
Simon Sumer, Bio-Techne
11:00 - 12:30
H 1
Silver Supporter
(Chair: Michaela Frye)
11:00 - 11:30 C04 - Rapid and consistent generation of functional hiPSC-derived microglia to accelerate drug discovery for neurodegenerative diseases
Malathi Raman,
11:30 - 12:00 C05 - Establishing an exosome isolation process - from stirred 3D-stem cell cultures to efficient isolation
Philipp Nold, Eppendorf SE
12:00 - 12:30 C06 - Highly customizable single-use bioreactors paving the way towards precision medicine
Parinaz Ashrafi, Dirk Otter​, Getinge
11:00 - 12:30
Silver & Bronze Supporter
(Chair: Ulrich Martin)
11:00 - 11:30 C07 - Efficient and seamless reprogramming using mRNA
Sebastian Knöbel, Miltenyi Biotec B.V. & Co. KG      
11:30 - 12:00 C08 - Identification of an FXR-modulated liver-intestine hybrid state in IPSC-derived hepatocyte-like cells
Patrick Nell, IfaDo, Dortmund for Takara Bio Europe, SAS
12:00 - 12:15 C09 - Next generation cytogenomics with optical genome mapping: quality assessment for cell bioprocessing
Julika Borde, Bionano
12:15 - 12:30 C10 - Chemically defined biomatrices for efficient isolation and manufacturing of stem cells
Richard Wetzel, denovoMATRIX GmbH    
11:00 - 12:30
H 3
Bronze Supporter 
(Chair: Nico Lachmann)
11:00 - 11:15 C11 - Gentle single-cell isolation technologies for generating clonal hiPSC cultures with market-leading efficiencies
Alex Feuerborn, iotaSciences
11:15 - 11:30 C12 - Reliable 3D Cell Models – High-Yield Cultivation Meets Precision Sorting
Markus Uhrig, OLS OMNI Life Science GmbH & Co. KG 
11:30 - 11:45 C13 - In vitro differentiation of human pluripotent stem cells: role in pancreatic development and diabetes research
Sandra Heller, Universitätsklinik Ulm for PeproTech GmbH, part of Thermo Fisher Scientific 
11:45 - 12:00 C14 - A large-scale standardized production workflow of 3D organoids and their use in high-throughput screening applications
Christian Holz, Molecular Devices (Germany) GmbH
12:00 - 12:15 C15 - Development of a Real-Time Assay for Tracking the Proliferation of iPSCs and iPSCderived  Organoids
Linda Boekestijn, Axion BioSystems
12:15 -12:30 C16 - Process development for efficient CAR T cell manufacturing using a closed and modular instrument workflow
Xavier De Mollerat Du Jeu, Thermo Fisher Scientific
12:30 - 14:00 Lunch break / Industry exhibition    supported by Molecular Devices GmbH
14:00 - 16:15
H 4/5
Presidential Symposium
Chair: Claudia Waskow
14:00 - 14:45 Presidential Invite
PS1 - Understanding and treating diabetes with islet stem cell models
Maike Sander, Max Delbrück Center Berlin
14:45 - 15:15 GSCN 2023 Young Investigator Award
PS2 - Dissecting pancreatic progenitor heterogeneity and early dysplasia using human pluripotent stem cells
Meike Hohwieler, University of Ulm
15:15 - 15:45 GSCN 2023 Hilde Mangold Award
PS3 - Modeling pancreas development with organoids
Anne Grapin-Botton, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
15:45 - 16:15 GSCN Publication of the Year 2022 - 2023 Award
PS4 - Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
Ruzhica Bogeska, German Cancer Research Center (DKFZ), Heidelberg
16:15 - 16:30 Break time / Industry exhibition                 supported by iotaSciences
16:30 - 18:30
Poster session II (Poster number P062 - P122)                                                                                             supported by Peprotech GmbH
(with beverages)
Computational stem cell biology: P062 - P066
Hematopoietic stem cells: P067 - P077
Pluripotency & reprograming: P078 - P084
Stem cells in aging & disease: P085 - P099
Stem cells in regenerative therapies: P100 - P122

Even numbers: 16:30 - 17:30
Odd number: 17:30 - 18:30
19:00 - 01:00 GSCN networking event for all participants                                                                                    supported by STEMCELL Technologies GmbH
The entrance fee is collected on site
Event location: 
Wiley Club
Wileystraße 4, 89231 Neu-Ulm

Friday, 15 September 2023

09:00 - 10:30 Concurrent scientific working group session III
09:00 - 10:30
H 1
Stem cell in regenerative therapies    supported by Eppendorf SE
(Chairs: Michael Cross / Wolfgang Wagner)
09:00 - 09:30 T32 - Advances in iPSC-based cellular therapies - preclinical evaluation and clinical trials
Ulrich Martin, Hannover Medical School (MHH)
09:30 - 09:45 T33 - iPSC-derived cultured red blood cells resemble fetal liver erythropoiesis
Isabel Dorn, Medical University Graz
09:45 - 10:00 T34 - Dissecting alpha and beta cell fate specification during human endocrinogenesis
Melis Akgün, Helmholtz Center Munich 
10:00 - 10:15 T35 - Inhibition of fatty acid oxidation impairs satellite cell quiescence and muscle regeneration by blocking the nuclear Acetyl-CoA production and histone acetylation
Xuejun Yuan, MPI for Heart and Lung Research, Bad Nauheim
10:15 - 10:30 T36 - Grafting postmitotic induced neurons: toward the establishment of defined human neuronal 3D networks
Jasmin Aicher, University of Bonn
09:00 - 10:30
H 2
Hematopoietic stem cells
(Chairs: Simon Haas / Michael Milsom
09:00 - 09:30 T37 - Deciphering how mitochondrial state impacts on hematopoietic stem cell fate
Els Mansell, Erasmus MC, Rotterdam, Netherlands
09:30 - 09:45 T38 - Hematopoietic stem and progenitor cell motility and cytoskeletal dynamics
Germán​ Camargo Ortega, ETH Zürich, Basel, Switzerland
09:45 - 10:00 T39 - Aging of human HSC niche and its impact on HSC function
Ani Grigoryan, Ulm University
10:00 - 10:15 T40 - Modulating hematopoietic stem cell activity by a vitamin A metabolite is beneficial for long-term recovery upon myocardial infarction
Jasmin Rettkowski, MPI for Immunobiology and Epigenetics,  Freiburg
10:15 - 10:30 T41 - Embryonic macrophages regulate the size of the definitive HSC pool
Gülce Percin, Leibniz Institute on Aging / FLI, Jena
09:00 - 10:30
H 3
Somatic stem cells & development
(Chairs: Thomas Braun / Ana Martin-Villalba)
09:00 - 09:18 T42 - Dynamics and functions of widespread RNA isoform changes during neuronal cell differentiation
Andreas Mayer, MPI for Molecular Genetics, Berlin
09:18 - 09:36 T43 - Unraveling heterogeneity and dynamics of muscle stem cell niches through integration of single-cell transcriptomics and advanced imaging
Josephine Bageritz, COS Heidelberg University 
09:36 - 09:54 T44 - Genetic dissection of in vivo direct cellular reprogramming
Ismail Özcan, University of Hamburg
09:54 - 10:12 T45 - Spatial transcriptomics reveal asymmetric cellular responses to injury in the regenerating spiny mouse (Acomys) ear
Kerstin Bartscherer, Osnabrück University
10:12 - 10:30 T46 - Derivation of human fetal-derived neuroepithelial progenitors mirroring the early stages of human brain development
Marcel Tisch, University of Innsbruck, Austria
10:30 - 11:00 Break time / Industry exhibition                     
11:00 - 12:30 Concurrent strategic working group session
11:00 - 12:30
H 4/5
Clinical trials & regulatory affairs
(Chairs: Zoltan Ivics / Torsten Tonn)
11:00 - 11:30 S1 - Developing a national strategy for gene and cell therapy
Christopher Baum, Berlin Institute of Health (BIH) at Charité
11:30 - 12:00 S2 - Stakeholders perspectives on the national strategy on gene and cell therapy
Zoltan Ivics, Paul Ehrlich Institute, Langen
12:00 - 12:30 S3 - Regulatory support in product development
Christoph Conrad, Berlin Institute of Health (BIH) at Charité
11:00 - 12:30
H 2
Career development
(Chairs: Germán Camargo / Insa Schröder)
  S4 - Power abuse in academia – what‘s the problem and what can be done?
Karin Höhne, Berlin Institute of Health (BIH) at Charité
11:00 - 12:30
H 3
Technologies in stem cell research
(Chairs: Andreas Bosio / Sebastian Diecke)
11:00 - 11:30 EMBO YIP Lecture
S5 - Clonally resolved single-cell multi-omics of leukemic and hematopoetic stem cells
Lars Velten, Centre for Genomic Regulation (CRG), Barcelona, Spain
11:30 - 12:00 S6 - Spatio-temporal, optogenetic control of gene expression in stem cells and organoids
Ivano Legnini, Human Technopole, Milano, Italy
12:00 - 12:30 S7 - Temporal topography of malignant brain tumors
Dieter Henrik Heiland, University hospital Freiburg
12:30 - 14:00 Lunch break / Industry exhibition      supported by Bionano
14:00 - 14:45
H 4/5
Keynote lecture IV & EMBO Keynote Lecture
K4 - Differentiation and dedifferentiation in mammalian epidermis
Fiona Watt, EMBL Heidelberg
Chair: Mareike Essers
14:45 - 15:30
H 4/5
Keynote lecture V
K5 - Multilayer control of plant stem cell behavior
Jan Lohmann, COS University Heidelberg
Chair: Heiko Lickert
15:30 - 15:50 Poster award ceremony
Daniel Besser
Poster awards    supported by Getinge
Travel awards    supported by Bio-Techne
15:50 - 16:00 Closing remarks by the GSCN president
Claudia Waskow 
  End of GSCN Conference 2023
Keynote Speakers 2023

Margaret Goodell (Houston, US)

Jan Lohmann (Heidelberg)

Hiromitsu Nakauchi (Stanford, US)

Nicolas Rivron (Vienna, Austria)

Maike Sander (Berlin)

Fiona Watt (Heidelberg)
EMBO Keynote Lecture

Speakers & Session Chairs

Sina Bartfeld (Berlin)
Aljoscha Berve (Düsseldorf)
Daniel Besser (Berlin)
Andreas Bosio (Bergisch Gladbach)
Thomas Braun (Bad Nauheim)
Oliver Brüstle (Bonn)
German Camargo Ortega (Basel)
Tobias Cantz (Hannover)
Michael Cross (Leipzig)
Sebastian Diecke (Berlin)
Micha Drukker (Leiden, NL)
Marieke Essers (Heidelberg)
Hartmut Geiger (Ulm)
Ingmar Glauche (Dresden)
Ira Herrmann (Bonn)
Alexander Kleger (Ulm)
Hannes Klump (Essen)
Nico Lachmann (Hannover)
Karl-Ludwig Laugwitz (Munich)
Heiko Lickert (Munich)
Stefan Liebau (Tübingen)
Carsten Marr (Munich)
Ulrich Martin (Hannover)  
Ana Martin-Villalba (Heidelberg)
Michael Rieger (Frankfurt a.M.)
Richard Schäfer (Frankfurt)
Insa Schröder (Darmstadt)
Hans Schöler (Münster)
Torsten Tonn (Dresden)
Andreas Trumpp (Heidelberg)
Wolfgang Wagner (Aachen)
Claudia Waskow (Jena)

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Gold Supporters

Life & Brain
StemCell Technologies

Silver Supporters


Bronze Supporters

Axion Bioscience
iota Sciences
Molecular Devices
OLS Omni
Thermo Fisher

Academic Supporters

Uni Ulm