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Program

Download the short program  here;
the complete program (including abstracts) can be downloaded  here.
The program is now also available as an  Online App.

Wednesday, 25 September 2024

11:00 - 11:30
H1
Opening
GSCN Conference 2024
11:00 - 11:08 Welcome to Jena University
Lars-Oliver Klotz, Dean of the Faculty of Biological Sciences, Friedrich-Schiller University, Jena
11:08 - 11:16 Welcome by the Medical Faculty
Thomas Kamradt, Scientific Director and Dean of the Faculty of Medicine, University Hospital Jena 
11:16 - 11:24 Welcome to Jena Science Campus
Dario Valenzano, Scientific Director, Leibniz Institute on Aging/FLI
11:24 - 11:30 Opening of GSCN Conference 2024 
Claudia Waskow, President GSCN
11:30 - 12:15
 
Keynote lecture I
K1 - Building stem cell models for women's health research
Amander Clark, Broad Stem Cell Research Center, UCLA, Los Angeles, US
Chair: Florian Heidel
12:15 - 13:00
 
Keynote lecture II
K2 - Towards reconstituting human & non-human primate axial development in vitro
Cantas Alev, ASHBi Kyoto University, JP
Chair: Sina Bartfeld
13:00 - 14:30 Lunch break / Industry exhibition    
14:30 - 16:00 Concurrent scientific working group session I
14:30 - 16:00
H1
Stem cell organoids                                                   supported by Getinge
(Chairs: Sina Bartfeld & Mina Gouti)
14:30 - 15:00 T01 - Infection and host cell tropism in the gut - organoids as model
Sina Bartfeld, TU Berlin
15:00 - 15:15 T02/P -  Human liver ductal cell heterogeneity and cell-state transitions in an organoid system
Javier Bregante Boixg, MPI-CBG Dresden
15:15 - 15:30 T03 - P53 activation in epithelial cells terminates the fetal-like regenerative state after colitis-associated injury
Kimberly Hartl, Charité Berlin
15:30 - 15:45 T04 - Cell type-specific epigenome profiling identifies H3K27me3 dynamics in the human developing neocortex
Mareike Albert, CRTD, TU Dresden
15:45 - 16:00 T05 - Assessing the impact of prenatal paracetamol exposure on early human forebrain development using cerebral organoids
Clara Hayn, University of Bonn
14:30 - 16:00
H2
Stem cells in aging & diseases   
(Chairs: Michael Rieger & Andreas Trumpp))
14:30 - 15:00 T06 - The role of leukemic stem cells in patients treated with the BCL-2 inhibitor venetoclax
Andreas Trumpp, Heidelberg Institute for Stem Cell Technology HI-STEM  
15:00 - 15:15 T07 - High fat diet impacts intestinal stem cell niche and causes hyperproliferation in the pig intestinal epithelium
Falk Farkas, Helmholtz Center Munich
15:15 - 15:30 T08 - Relevance of dormant cancer stem cells in disease propagation and therapy resistance in JAK2V617F-driven myeloproliferative neoplasms
Ian Ghezzi, DKFZ Heidelberg
15:30 - 15:45 T09 - Targeting SRSF2 mutations in leukemia with RKI-1447: a method to disrupt HSC division and alter nuclear formation
Natalie Kaushansky, Weizman Institute, Rehovot, IL
15:45 - 16:00 T10 - The inflammatory connection: insights from spatial mapping of human hematopoiesis in aging and blood malignancies
Borhane Guezguez, University of Mainz
14:30 - 16:00
H3
Computational stem cell biology
(Chairs: Ingmar Glauche & Carsten Marr
14:30 - 15:00 T11 - Hematopoiesis by the numbers: advances in cellular barcoding and counting cell division
Leila Perié, Curie Institute, Paris, FR
15:00 - 15:15 T12/P - A scalable computational framework for annotation-independent combinatorial target identification in scRNA-seq databases
Maximilian Buser, Helmholtz Center Munich
15:15 - 15:30 T13 - Tracking bone marrow regeneration after CAR-T cell therapy in myeloma at spatial single-cell resolution
Jennifer Wing Lam Cheung, University Würzburg 
15:30 - 15:45 T14 - Inferring the clonal dynamics of development from holistic barcoding: theory and application to tissue macrophages
Maurice Langhinrichs, DKFZ Heidelberg
15:45 - 16:00 T15/P - Unveiling the mechanisms of macrophage-mediated cytokine release syndrome in CAR-T cell therapy with mathematical modeling
Artur César Fassoni, TU Dresden
16:00 - 16:30 Break time / Industry exhibition     
16:30 - 17:30
H3
General Meeting
Executive Board & Managing Director
Claudia Waskow, Hans Schöler, Heiko Lickert, Michael Cross, Andreas Trumpp, Daniel Besser
17:30 - 19:30
Foyer + H 6 
(1st floor)
Poster session I  (Poster number P001 - P064)
(with beverages)                                                                         supported by PeptiGrowth
Disease modeling & drug development: P001 - P038
Hematopoietic stem cells: P039 - P054
Pluripotency & reprograming: P054 - P064


Even numbers: 17:30 - 18:30
Odd numbers: 18:30 - 19:30
19:45 -20:30
H1
Keynote lecture III (on ELSA topics)
K3 - Consciousness as an ethical issue in neural organoid research
Garðar Ágúst Árnason, University of Akureyri, IS
Chair: Tobias Cantz
20:30 - 22:00
Mensa 
Philosophenweg
GSCN Get-together for all participants
Dinner buffet at the Mensa Philosophenweg 20
(10-minute walk from the Friedrich Schiller University)
 
  Top

 

Thursday, 26 September 2024
 

 
09:00 - 10:30 Concurrent scientific working group session II
09:00 - 10:30
H1
Pluripotency, somatic stem cells & development 
(Chairs: Thomas Braun & Hans Schöler)
09:00 - 09:30 T16 - Capture of human axial stem cells
Micha Drukker, Stem Cell Technology for Microphysiological Modeling, Leiden University, NL 
09:30 - 09:45 T17 - The homeobox transcription factor DUXBL controls toti- to pluripotent transition
Felipe Lüttmann, TRON Mainz
09:45 - 10:00 T18 - SOX and POU transcription factors are older than stem cells and animals
Ralf Jauch, University of Hong Kong, HK
10:00 - 10:15 T19/P - Lifelong persistence of nuclear RNAs in the rodent brain
Sara Zocher, DZNE Dresden
10:15 - 10:30 T20 - Epithelial-stromal communication via BMP signaling is a critical regulator of site specificity in the mouse oral mucosa
Kai Kretzschmar, Uni Würzburg
09:00 - 10:30
H2
HEAL Symposium
(Chairs: Ulrich MartinRobert Zweigerdt)
 
09:00 - 09:30 T21 - Advancing cardiac therapeutics from animals to patients
Eldad Tzahor, Weizmann Institute of Science, Rehovot, IL 
09:30 - 09:45 T22 - Lineage-specific cancer-related mutations in human pluripotent and adult stem cells
Jonathan Jung, Hebrew University of Israel, Jerusalem, IL
09:45 - 10:00 T23 - HLA-homozygous GMP iPSCs show efficient cardiac induction on a new differentiation platform featuring scalability and enhanced robustness
Soraia Martins, Catalent, Langenfeld
10:00 - 10:15 T24 - hPSC-cardiomyocyte production: standardization and protein-free upscaling to 2000 mL
Niels Kriedemann, MH Hannover
10:15 - 10:30 T25/P - Optimization of cardiomyocyte cryopreservation and quality control aspects for potency and residual iPSC contaminations
Fabienne Becker, University Düsseldorf
09:00 - 10:30
SR114
ELSA symposium: 
(Chairs: Stefan Hoffmann & Tobias Cantz)
Panelists: Garðar Ágúst Árnason​ & others
10:30 - 11:00 Break time / Industry exhibition        
11:00 - 12:30 Industry session: "Technologies from GSCN industry partners"
11:00 - 12:30
H1
Supporter I
(Chair: Helen MorrisonHarald Stachelscheid)
11:00 - 11:15 C01 - Assay-ready human microglia for automated image-based phenotypic subgrouping and targeted compound screening
Michael Peitz, LIFE & BRAIN GmbH (Bronze Supporter)
11:15 - 11:30 C02 - Advancing stem cell research with automated detection and isolation of stem cells and colonies
Jurij Kintz, Sartorius Stedim Biotech GmbH (Bronze Supporter)
11:30 -12:00 C03 - Improved genetic stability of human pluripotent stem cell cultures passaged as single cells using eTeSR™
Adam Hirst, STEMCELL Technologies UK Ltd. (Gold Supporter)
12:00 - 12:20 C04 - Harnessing CRISPR-ready human iPSC derived cells for disease modeling and drug discovery in neurodegenerative diseases
Rebecca Northeast,  bit.bio (Silver Supporter)
11:00 - 12:30
H2
Supporter II
(Chair: Hartmut Geiger / Anne Grapin-Botton)
11:00 - 11:15 C05 - Take your research translational the easy way: streamline your cell culture
with our ready-to-use products and automated solutions
Volker Arps, Bio-Techne (Bronze Supporter)
11:15 - 11:35 C06 - Bioreactor systems | cell & gene therapy applications | state-of-the-art
Sascha Gandert, Getinge (Silver Supporter)
11:35 - 11:55 C07 - NK cell generation from iPSC suspension cultures
Sara Pérez Muñoz, Thermo Fisher Scientific (Silver Supporter)
11:55 - 12:15 C08 - From R&D to manufacturing: the cell as a product
Philipp Nold, Eppendorf SE (Silver Supporter)
12:15 -12:30 C09 - Innovative synthetic peptide-based growth factor : overcoming challenges in stem cell medicine production
Robert Brownlee, PeptiGrowth  (Bronze Supporter)
12:30 - 14:00 Lunch break / Industry exhibition                           supported by LIFE & BRAIN
14:00 - 16:15
H1
Presidential Symposium
Chair: Claudia Waskow
14:00 - 14:45 Presidential Invite
PS1 - Deconvolution of stem and progenitor cell fates and immune lineages by polylox barcoding
Hans-Reimer Rodewald, German Cancer Research Center (DKFZ), Heidelberg
14:45 - 15:15 GSCN 2024 Young Investigator Award
PS2 - Fetal-maternal interface across species
Claudia Gerri, MPI-CBG Dresden
15:15 - 15:45 GSCN 2024 Hilde Mangold Award
PS3 - Building the next generation of neuromuscular models to study disease
Mina Gouti, MDC Berlin
15:45 - 16:15 GSCN Publication of the Year 2023 - 2024 Award
PS4 - A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals
Jorge Lázaro, TU Dresden & EMBL Barcelona, ES
16:15 - 16:30 Break time / Industry exhibition                 
16:30 - 18:30
Foyer + H 6 
(1st floor)
Poster session II (Poster number P065 - P126)
(with beverages)                                               supported by bio-techne
Stem cells in aging & disease: P065 - P077
Computational stem cell biology & sytems biology: P078 - P082
Stem cell organoids: P083 - P105
Stem cells in regenerative therapies: P106 - P121
Somatic stem cells & development: P122 - P126
Late Poster: PX01 - PX03


Even numbers: 16:30 - 17:30
Odd number: 17:30  - 18:30
19:00 - 01:00 GSCN networking event for all participants
                                                         
supported by STEMCELL Technologies
The entrance fee is collected on site
Event location: 
Volksbad Jena
Knebelstraße 10, 07743 Jena

Friday, 27 September 2024
 

09:00 - 10:30 Concurrent scientific working group session III
09:00 - 10:30
H1
Stem cell in disease modeling & drug development
                                                                         
supported by bit.bio
(Chairs: Oliver BrüstleKarl-Ludwig Laugwitz)
09:00 - 09:30 T26 - iPSCs in drug discovery – from a user’s and a personal perspective
Bert Klebl, Lead Discovery Center (LDC), Dortmund
09:30 - 09:45 T27 - Patient-specific iPSC-derived hepatic organoids as model for drug dosing and mRNA-based gene therapy
Malte Sgodda, Hannover Medical School (MHH)
09:45 - 10:00 T28 - Human multi-tissue organoids as an advanced teratogenicity model
Liam Wilson, Hannover Medical School (MHH)
10:00 - 10:15 T29 - Cellular metabolism senses exogenous fatty acids to reprogram dormant tumour cells into aggressive oncogenic cell states
Patricia Inacio, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
10:15 - 10:30 T30 - iPSC modeling of bipolar disorder 1 based on polygenic risk scores
Tamara Krutenko, University of Bonn
09:00 - 10:30
H2
Hematopoietic stem cells
(Chairs: Marieke Essers & Mick Milsom
09:00 - 09:30 T31 - The bonemarrow niche under stress
Marieke Essers, DKFZ & HI-Stem, Heidelberg
09:30 - 09:45 T32 - Apelin signaling restricts the formation of the blood stem cell-forming hemogenic endothelium
Jean Eberlein, University of Marburg
09:45 - 10:00 T33/P - Intrinsic reconstitution potential of developmentally restricted hematopoietic stem cells in non-conditioned immunocompromised mice
Marcel G.E. Rommel, UC Santa Cruz
10:00 - 10:15 T34 - Metabolic atlas of human bone marrow hematopoietic stem cells upon differentiation, aging and leukemia
Maria Eleni Lalioti, MPI-IE, Freiburg
10:15 - 10:30 T35 - The function of PD-L2 expression on human hematopoietic stem cells in allogeneic immune regulation at single cell resolution
Tessa Schmachtel, University Hospital Frankfurt
09:00 - 10:30
H3
Stem cells in regenerative therapies                   supported by Eppendorf SE
(Chairs: Michael Cross & Ulrich Martin)
09:00 - 09:30 T36 - Tracking of early cell fate decisions of iPSCs based on DNA methylation
Wolfgang Wagner, RWTH Aachen
09:30 - 09:45 T37 - Pooled mesenchymal stromal cells fail to represent average donor cell characteristics
Janina Burk, vetmeduni, Vienna, AT
09:45 - 10:00 T38/P - Humanized osteoclasts: an interspecies chimeric immune cell
Gülce Percin, Leibniz Institute on Aging/FLI, Jena 
10:00 - 10:15 T39 - Resolving human alpha versus beta cell fate allocation for the generation of stem cell-derived islets
Corinna Cozzitorto, Helmholtz Center Munich
10:15 - 10:30 T40 - Generation of designer stem cell-derived islets (SC-islets) to improve safety and efficacy of SC-based islet replacement therapy
Eunike Setyono, Helmholtz Center Munich
10:30 - 11:00 Break time / Industry exhibition                     
11:00 - 12:30 Concurrent strategic working group session
11:00 - 12:30
H1
Clinical trials & regulatory affairs
(Chairs: Zoltán Ivics & Andreas Kurtz)
11:00 - 11:30 S1 - Exploring public and government funding opportunities
Bettina Otto, Berlin Institute of Health (BIH)
11:30 - 12:00 S2 - High-Tech Gründerfonds - early stage seed investments
Christian Kannemeier, High-Tech Gründerfonds, Berlin
12:00 - 12:30 S3 - The National Office for Gene- and Cell Therapies (GCT): updates on activities and future impact
Elke Luger, GCT National Network Orrice, Berlin
11:00 - 12:30
H2
Career development
(Chairs: Marieke Essers & Insa Schroeder)
  S4 - Publish or perish - feed back from a journal editor
Achim Breiling, EMBO Reports, Heidelberg
11:00 - 12:30
H3
Technologies in stem cell research
(Chairs: Sebastian Diecke & Sebastian Knöbel)
11:00 - 11:30 S5 - Cellular microenvironments fabricated with fluid walls for disease modeling
Edmond Walsh, University of Oxford, UK
11:30 - 12:00 S6 - Combining stem cell and device engineering for in vitro models of human physiology
Anna Herland, KTH Royal Institute of Technology, Solna, SE
12:00 - 12:30 S7 - Stem cell-derived vessels-on-chip for cardiovascular disease modeling
Matthias Meier, Helmholtz Center Munich
12:30 - 14:00 Lunch break / Industry exhibition                            supported by Sartorius
14:00 - 14:45
H1
Keynote lecture IV
K4 - Colorful aging? an aging-specific platelet differentiation path from hematopoietic stem cells
Camilla Forsberg, UC Santa Cruz, US
Chair: Meritxell Huch
14:45 - 15:30
H1
Keynote lecture V
K5 - Bat induced pluripotent stem cells as a model for viral tolerance and immunity
Thomas Zwaka, Icahn School of Medicine at Mount Sinai, New York, US
Chair: Heiko Lickert

15:30 - 15:50
H1

Poster award ceremony
Daniel Besser
Poster awards                      supported by Thermo Fisher Scientific
Travel awards   
15:50 - 16:00
H1
Closing remarks by the GSCN president
Heiko Lickert 
  End of GSCN Conference 2024
  Top
Keynote Speakers 2024


Garðar Ágúst Árnason (Akureyri, Iceland)


Cantas Alev (Kyoto, Japan)


Amander Clark (Los Angeles, US)


Camilla Forsberg (Santa Cruz, US)


Hans-Reimer Rodewald (DKFZ, Heidelberg)


Thomas Zwaka (New York, US)

Speakers & Session Chairs

Sina Bartfeld (Berlin)
Daniel Besser (Berlin)
Thomas Braun (Bad Nauheim)
Oliver Brüstle (Bonn)
Nina Cabezas Wallscheid (Freiburg)
Tobias Cantz (Hannover)
Michael Cross (Leipzig)
Sebastian Diecke (Berlin)
Micha Drukker (Leiden, NL)
Marieke Essers (Heidelberg)
Hartmut Geiger (Ulm)
Ingmar Glauche (Dresden)
Mina Gouti (Berlin)
Anne Grapin-Botton (Dresden)
Florian Heidel (Hannover)
Ira Herrmann (Bonn)
Stefan Hoffmann (Düsseldorf)
Meritxell Huch (Dresden)
Zoltán Ivics (Langen)
Ralf Jauch (Hongkong) supported by Centre for Translational Stem Cell Biology (CTSCB), Hong Kong
Bert Klebl (Dortmund)
Hannes Klump (Essen)
Sebastian Knöbel (Bergisch Gladbach)
Andreas Kurtz (Berlin)
Nico Lachmann (Hannover)
Karl-Ludwig Laugwitz (Munich)
Heiko Lickert (Munich)
Stefan Liebau (Tübingen)
Carsten Marr (Munich)
Ulrich Martin (Hannover)
Mick Milsom (Heidelberg)
Helen Morrison (Jena)
Michael Rieger (Frankfurt a.M.)
Insa Schröder (Darmstadt)
Hans Schöler (Münster)
Harald Stachelscheid (Berlin)
Andreas Trumpp (Heidelberg)
Wolfgang Wagner (Aachen)
Claudia Waskow (Jena)
Robert Zweigerdt (Hannover)

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Gold Supporters

Stem Cell Technologies

Silver Supporters

bit.bio
Eppendorf
Getinge
Thermo Fisher Scientific

Bronze Supporters

Bio-Techne
Life & Brain GmbH
Peptigrowth
Sartorius

Academic Supporters

FLI Jena
BIH
FSU Jena
BMBF