| 09:00 - 10:30 |
Concurrent scientific working group session II |
09:00 - 10:30
H 1 |
Stem cells in disease modeling & drug development II
(Chairs: Bert Klebl / Harald Stachelscheid) |
| 09:00 - 09:15 |
T16 - TPP1 gene therapy ablates disease phenotype in neuronal ceroid lipofuscinosis type 2 in retinal organoid and retina-on-chip models
Kevin Achberger, University of Tübingen |
| 09:15 - 09:30 |
T17 - A human iPSC model of Tauopathies engineered for adult Tau isoform expression displays late-stage neuronal Tau pathology
Angelika Dannert, Ludwig Maximilians University (LMU), Munich |
| 09:30 - 09:45 |
T18 - Beyond cell-autonomous phenotypes: multi-compartment modeling of human nociception
Pascal Röderer, University of Bonn |
| 09:45 - 10:00 |
T19 - An isogenic human iPSC model unravels neurodevelopmental abnormalities in spinal muscular atrophy
Natalia Rodriguez-Muela, German Center for Neurodegenerative Diseases (DZNE), Dresden |
| 10:00 - 10:15 |
T20 - Characterizing the neurotoxic effects of paclitaxel in human induced pluripotent stem cell (iPSC)-derived sensory neurons in a multi-omic approach
Christian Schinke, Charité - Berlin University Medicine |
| 10:15 - 10:30 |
T21 - Modeling metastatic cancer niches for drug discovery using human iPSC-derived brain organoids
Ole Pless, Fraunhofer ITMP Hamburg |
09:00 - 10:30
H 2 |
Stem cell organoids
(Chairs: Sina Bartfeld / Mina Gouti) |
| 09:00 - 09:30 |
T22 - 3D electrically excitable cell networks - from brain to heart
Maria-Patapia Zafeiriou, University Medical Center Göttingen |
| 09:30 - 09:45 |
T23 - Inducing lung differentiation in human heart-forming organoids to form complex lung-HFOs
Lika Drakhlis, Hannover Medical School (MHH) |
| 09:45 - 10:00 |
T24 - Development of a skin cancer model using melanoma tumor spheroids and skin organoids
Dieter Groneberg, Fraunhofer-Institute for Silicate Research ISC, Würzburg |
| 10:00 - 10:15 |
T25 - Modeling Johanson-Blizzard syndrome (JBS) in a dish – molecular insights into UBR1 deficiency using pluripotent stem cell-derived pancreatic organoids
Leon Reichardt, Ulm University |
| 10:15 - 10:30 |
T26 - Generating fetal liver organoids with innate immunopoiesis from human pluripotent stem cells
Milad Rezvani, Charité - Berlin University Medicine |
09:00 - 10:30
H 3 |
Stem cells in ageing & disease
(Chairs: Michael Rieger / Andreas Trumpp) |
|
| 09:00 - 09:30 |
T27 - Bone marrow stromal dysregulations in clonal hematopoiesis and related myelodysplasia promote an inflammatory-stress T cell landscape
Borhane Guezguez, DKTK - University Medical Center Mainz |
| 09:30 - 09:45 |
T28 - Ontogenetic and functional heterogeneity of tissue resident macrophages during aging and systemic inflammation
Stephan Culemann, Leibniz Institute on Aging/FLI, Jena |
| 09:45 - 10:00 |
T29 - Single-cell barcoding delineates a differentiation hierarchy of leukemia-initiating stem cells in adult acute lymphoblastic leukemia
Alec Geßner, Goethe University Hospital, Frankfurt |
| 10:00 - 10:15 |
T30 - Stem cell-niche interactions control leukemic expansion: conceptual insights from the mathematical modeling of acute myeloid leukemia
Ingmar Glauche, Technical University (TU) Dresden |
| 10:15 - 10:30 |
T31 - Elevated levels of Ube2g1 expression in HSCs leads to premature aging of the hematopoietic system
Julian Niemann, Ulm University |
09:00 - 10:30
tbd |
ELSA symposium: What makes it (not) a human being?
(Chairs: Aljoscha Berve / Tobias Cantz)
Panelists: Nicolas Rivron & Hiromitsu Nakauchi |
| 09:00 - 09:05 |
Welcome and introduction
Tobias Cantz, Hannover Medical School |
| 09:05 - 09:15 |
Interview Nicolas Rivron with Aljoscha Berve, Stemcell Network NRW, Düsseldorf
What is your definition of embryoids, blastoids, self-assembled embryos and do these differences matter?
Do you think the term “synthetic embryo” is justified”?
What are your expectations on advanced embryoid cultivation in 10 years?
How do differing international regulations affect your current research?
Do you experience global differences in acceptance / funding options of your research? |
| 09:15 - 09:25 |
Interview Hiromitsu Nakauchi with Tobias Cantz
What are your expectations on the use of human-animal chimera for organ development in 10 years?
If an organ is generated by embryo complementation with patient-derived iPS cells. Who owns the organ?
Germline contribution of human cells is a critical issue. But to what extent does neural chimerism matter?
How do differing international regulations affect your current research?
Do you experience global differences in acceptance / funding options of your research? |
| 09:25 - 10:15 |
Panel discussion / plenum:
What characteristics are missing to make an embryoid a human being? And, what is missing to make a chimeric animal a human being?
Subsequent to the term “synthetic embryo”, do we have to contemplate the term “synthetic human being”?
Are there “safety switches” that would address major doubts?
Could we envision a road map that guides a step-wise development advanced embryoids human-animal chimeras? |
| 10:15 - 10:20 |
Concluding remarks
Aljoscha Berve |
| 10:20 - 10:30 |
Civey survey on embryo research regulation in Germany
How does the German (internet) public feel about embryo research regulation?
Daniel Besser |
| 10:30 - 11:00 |
Break time / Industry exhibition supported by Axion BioSystems |
| 11:00 - 12:30 |
Industry session: "Technologies from GSCN industry partners" |
11:00 - 12:30
H 4/5 |
Gold & Silver Supporter
(Chair: Michael Cross) |
| 11:00 - 11:30 |
C01 - Life & Brain integrated services: molecular karyotyping for cost-effective quality control of stem cell systems
Michael Peitz, Life & Brain GmbH |
| 11:30 - 12:00 |
C02 - Enhanced genetic stability of human pluripotent stem cells maintained as single cells under optimized culture conditions
Kimberly Snyder, STEMCELL Technologies Inc., Vancouver, BC, Canada |
| 12:00 -12:30 |
C03 - Replace, Reduce, and Refine with Bio-Techne – kick-start your animal-free research
Simon Sumer, Bio-Techne |
11:00 - 12:30
H 1 |
Silver Supporter
(Chair: Michaela Frye) |
| 11:00 - 11:30 |
C04 - Rapid and consistent generation of functional hiPSC-derived microglia to accelerate drug discovery for neurodegenerative diseases
Malathi Raman, bit.bio |
| 11:30 - 12:00 |
C05 - Establishing an exosome isolation process - from stirred 3D-stem cell cultures to efficient isolation
Philipp Nold, Eppendorf SE |
| 12:00 - 12:30 |
C06 - Highly customizable single-use bioreactors paving the way towards precision medicine
Parinaz Ashrafi, Dirk Otter, Getinge |
11:00 - 12:30
H2 |
Silver & Bronze Supporter
(Chair: Ulrich Martin) |
| 11:00 - 11:30 |
C07 - Efficient and seamless reprogramming using mRNA
Sebastian Knöbel, Miltenyi Biotec B.V. & Co. KG |
| 11:30 - 12:00 |
C08 - Identification of an FXR-modulated liver-intestine hybrid state in IPSC-derived hepatocyte-like cells
Patrick Nell, IfaDo, Dortmund for Takara Bio Europe, SAS |
| 12:00 - 12:15 |
C09 - Next generation cytogenomics with optical genome mapping: quality assessment for cell bioprocessing
Julika Borde, Bionano |
| 12:15 - 12:30 |
C10 - Chemically defined biomatrices for efficient isolation and manufacturing of stem cells
Richard Wetzel, denovoMATRIX GmbH |
11:00 - 12:30
H 3 |
Bronze Supporter
(Chair: Nico Lachmann) |
| 11:00 - 11:15 |
C11 - Gentle single-cell isolation technologies for generating clonal hiPSC cultures with market-leading efficiencies
Alex Feuerborn, iotaSciences |
| 11:15 - 11:30 |
C12 - Reliable 3D Cell Models – High-Yield Cultivation Meets Precision Sorting
Markus Uhrig, OLS OMNI Life Science GmbH & Co. KG |
| 11:30 - 11:45 |
C13 - In vitro differentiation of human pluripotent stem cells: role in pancreatic development and diabetes research
Sandra Heller, Universitätsklinik Ulm for PeproTech GmbH, part of Thermo Fisher Scientific |
| 11:45 - 12:00 |
C14 - A large-scale standardized production workflow of 3D organoids and their use in high-throughput screening applications
Christian Holz, Molecular Devices (Germany) GmbH |
| 12:00 - 12:15 |
C15 - Development of a Real-Time Assay for Tracking the Proliferation of iPSCs and iPSCderived Organoids
Linda Boekestijn, Axion BioSystems |
| 12:15 -12:30 |
C16 - Process development for efficient CAR T cell manufacturing using a closed and modular instrument workflow
Xavier De Mollerat Du Jeu, Thermo Fisher Scientific |
| 12:30 - 14:00 |
Lunch break / Industry exhibition supported by Molecular Devices GmbH |
14:00 - 16:15
H 4/5 |
Presidential Symposium
Chair: Claudia Waskow |
| 14:00 - 14:45 |
Presidential Invite
PS1 - Understanding and treating diabetes with islet stem cell models
Maike Sander, Max Delbrück Center Berlin |
| 14:45 - 15:15 |
GSCN 2023 Young Investigator Award
PS2 - Dissecting pancreatic progenitor heterogeneity and early dysplasia using human pluripotent stem cells
Meike Hohwieler, University of Ulm |
| 15:15 - 15:45 |
GSCN 2023 Hilde Mangold Award
PS3 - Modeling pancreas development with organoids
Anne Grapin-Botton, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden |
| 15:45 - 16:15 |
GSCN Publication of the Year 2022 - 2023 Award
PS4 - Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
Ruzhica Bogeska, German Cancer Research Center (DKFZ), Heidelberg |
| 16:15 - 16:30 |
Break time / Industry exhibition supported by iotaSciences |
16:30 - 18:30
Foyer |
Poster session II (Poster number P062 - P122) supported by Peprotech GmbH
(with beverages)
Computational stem cell biology: P062 - P066
Hematopoietic stem cells: P067 - P077
Pluripotency & reprograming: P078 - P084
Stem cells in aging & disease: P085 - P099
Stem cells in regenerative therapies: P100 - P122
Even numbers: 16:30 - 17:30
Odd number: 17:30 - 18:30 |
| 19:00 - 01:00 |
GSCN networking event for all participants supported by STEMCELL Technologies GmbH
The entrance fee is collected on site
Event location: ➚ Wiley Club
Wileystraße 4, 89231 Neu-Ulm |